The cause of lipoma is still not defined, but a common factor seems to be hereditary. Some conditions may cause lipoma, and these include:
Dercum's disease is a rare disorder that causes painful lipomas to grow, most often on the arms, legs and trunk. The condition is also known as adiposis dolorosa or Anders' syndrome.
Gardner syndrome is a form of a disorder called familial adenomatous polyposis (FAP). It causes lipomas and also a range of other health problems.
Hereditary multiple lipomatosis is inherited and also known as Familial multiple lipomatosis (FML).
Madelung's disease occurs in men who indulge in excessive alcohol consumption risk developing this condition, also known as multiple symmetric lipomatosis. The condition causes lipoma to form around the neck and shoulders.